The SKELETONS are driven off by your completely gentlemanly assault with CITIZEN CANE. They--- wait, there are three of them now? Whatever. The SKELETONS are driven off and heading EAST, fleeing the room.
With your precious HANDCART safe, you continue your INVESTIGATION and lift the PLAGUE DOCTOR / DEATH PORTRAIT off the wall.
Hey, a PUZZLE! It's... been a while. What have we here?
The PLAQUE reads "What comes once per minute, twice in a moment, but never in a thousand years?" There are six SLOTS below the PLAQUE, and below that there's a SHELF with seven SCRABBLE TILES.
If you're right about this, and it might be a bit of a stretch, but maybe, just maybe you're supposed to use the SCRABBLE TILES to answer the RIDDLE? Man, this is complicated. Maybe you should just drink that ROSÉ the ZOMMOLIER poured and forget the whole thing.